Blocking Pseudomonas Aeruginosa, Chromobacterium Violaceum, and Ralstonia Solanacearum Adhesion by Fruit Glycans
نویسندگان
چکیده
P. aeruginosa produces two lectins: PA-IL (LecA) (that bind galactose [Gal] and L-arabinose [Ara]), and PA-IIL (LecB) (that binds fucose [Fuc] > mannose [Man] and fructose [Fru]) [5,6]. These lectins contribute to the pathogens adhesion to target cells [7] and amplify the destructive effects of their accompanying virulence factors on those cells [8]. They also contribute to the pathogen auto-aggregation into biofilms [6], increasing its adhesion to victim host tissues and hampering antibacterial agent penetration into its cells [9].
منابع مشابه
Preventing Pseudomonas aeruginosa and Chromobacterium violaceum infections by anti-adhesion-active components of edible seeds
BACKGROUND Pseudomonas aeruginosa adhesion to animal/human cells for infection establishment involves adhesive proteins, including its galactose- and fucose-binding lectins PA-IL (LecA) and PA-IIL (LecB). The lectin binding to the target-cell receptors may be blocked by compatible glycans that compete with those of the receptors, functioning as anti-adhesion glycodecoys. The anti-adhesion treat...
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